Mitochondrial Redox Control of Angiogenesis revised submission, 12/23/2004 MITOCHONDRIAL H2O2 REGULATES THE ANGIOGENIC PHENOTYPE VIA PTEN OXIDATION
نویسندگان
چکیده
Centers for Immunology & Microbial Disease, Neuropharmacology & Neuroscience and Cell biology and Cancer Research, Albany Medical College, 47 New Scotland Ave., Albany, NY 12208. Harvard Medical School,M551, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115. Structural and Cell Biology Department of Biomedical Sciences School of Public Health, University at Albany, One University Place, Rensselaer, NY 12144. Webb-Waring Institute for Cancer, Aging and Antioxidant Research, University of Colorado Health Sciences Center, Denver, Colorado 80262. Running Title: Mitochondrial Redox Control of Angiogenesis.
منابع مشابه
Mitochondrial H2O2 regulates the angiogenic phenotype via PTEN oxidation.
Recent studies have demonstrated that the tumor suppressor PTEN (phosphatase and tensin homolog deleted from chromosome 10), the antagonist of the phosphosphoinositol-3-kinase (PI3K) signaling cascade, is susceptible to H2O2-dependent oxidative inactivation. This study describes the use of redox-engineered cell lines to identify PTEN as sensitive to oxidative inactivation by mitochondrial H2O2....
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